Ontology highlight
ABSTRACT:
SUBMITTER: Sehgal P
PROVIDER: S-EPMC8327952 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Sehgal Paras P Mathew Samatha S Sivadas Ambily A Ray Arjun A Tanwar Jyoti J Vishwakarma Sushma S Ranjan Gyan G Shamsudheen K V KV Bhoyar Rahul C RC Pateria Abhishek A Leonard Elvin E Lalwani Mukesh M Vats Archana A Pappuru Rajeev R RR Tyagi Mudit M Jakati Saumya S Sengupta Shantanu S B K Binukumar B Chakrabarti Subhabrata S Kaur Inderjeet I Motiani Rajender K RK Scaria Vinod V Sivasubbu Sridhar S
The EMBO journal 20210628 15
Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a novel vascular endothelial-associated lncRNA (VEAL2) in regulating endothelial permeability. Precise editing of veal2 loci in zebrafish (veal2<sup>gib005Δ8/+</sup> ) induced cranial hemorrhage. In vitro and in vivo studies revealed that veal2 competes with diacylglycerol for interaction with protein kinase C beta-b (Prkcbb) and regulates its kinase activity. Using PRKCB ...[more]