The Genetic Contribution to Drug Response in Spondyloarthritis: A Systematic Literature Review.

ABSTRACT: Objective: Spondyloarthritis (SpA) are a group of diseases with a high heritability, whose pathogenesis is strongly determined by an interplay between genetic and environmental factor. Therefore, the aim of our study was to determine whether genetic variants could also influence response to therapy in SpA. Methods: A systematic literature review (SLR) was conducted in PubMed and Web of Science core collection, without publication-year restrictions (Last search 8th April 2021). The search strategy was formulated according to the PEO format (Population, Exposure, Outcome) for observational studies. The population was adult (≥18 years) patients with SpA. The exposure was inheritable genetic variations of any gene involved in the disease pathogenesis/drug metabolism. The outcome

SUBMITTER: Ortolan A 

PROVIDER: S-EPMC8329488 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature