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PARP inhibition in the ovarian cancer patient: Current approvals and future directions.

ABSTRACT: Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed the therapeutic management of solid tumors, particularly ovarian cancer. Initially studied in BRCA deficient tumors, the Food and Drug Administration (FDA) indications have expanded to include other homologous recombination deficient tumors as well as biomarker-wildtype tumors. They have also gained momentum not only as a treatment strategy, but as a maintenance strategy as well. While PARP inhibitors were initially ev aluated in the recurrent setting, they have now moved to frontline therapy. This review will discuss the current FDA indications of the clinically available PARP inhibitors for treatment and maintenance therapies. We will then review the recently completed and ongoing clinical trials which may inform future clinical approvals.

SUBMITTER: Kurnit KC

PROVIDER: S-EPMC8331065 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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PARP inhibition in the ovarian cancer patient: Current approvals and future directions.

Kurnit Katherine C KC Avila Monica M Hinchcliff Emily M EM Coleman Robert L RL Westin Shannon N SN

Pharmacology & therapeutics 20200523

Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed the therapeutic management of solid tumors, particularly ovarian cancer. Initially studied in BRCA deficient tumors, the Food and Drug Administration (FDA) indications have expanded to include other homologous recombination deficient tumors as well as biomarker-wildtype tumors. They have also gained momentum not only as a treatment strategy, but as a maintenance strategy as well. While PARP inhibitors were initially ev aluated in th ...[more]

PMID: 32450190

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Dataset Information

PARP inhibition in the ovarian cancer patient: Current approvals and future directions.

Publications

PARP inhibition in the ovarian cancer patient: Current approvals and future directions.

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