Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19.

ABSTRACT: A spectrum of neurological disease associated with COVID-19 is becoming increasingly apparent. However, the mechanisms behind these manifestations remain poorly understood, significantly hindering their management. The present review subsequently attempts to address the evolving molecular, cellular and systemic mechanisms of NeuroCOVID, which we have classified as the acute and long-term neurological effects of COVID-19. We place particular emphasis on cerebrovascular, demyelinating and encephalitic presentations, which have been reported. Several mechanisms are presented, especially the involvement of a "cytokine storm". We explore the genetic and demographic factors that may predispose individuals to NeuroCOVID. The increasingly evident long-term neurological effects are also presented,

SUBMITTER: Jesuthasan A 

PROVIDER: S-EPMC8332920 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature