Impaired Cerebrovascular Reactivity in Huntington's Disease.

ABSTRACT: There is increasing evidence that impairments of cerebrovascular function and/or abnormalities of the cerebral vasculature might contribute to early neuronal cell loss in Huntington's disease (HD). Studies in both healthy individuals as well as in patients with other neurodegenerative disorders have used an exogenous carbon dioxide (CO₂) challenge in conjunction with functional magnetic resonance imaging (fMRI) to assess regional cerebrovascular reactivity (CVR). In this study, we explored potential impairments of CVR in HD. Twelve gene expanded HD individuals, including both pre-symptomatic and early symptomatic HD and eleven healthy controls were administered a gas mixture targeting a 4-8 mmHg increase in CO₂ relative to the end-tidal partial pressure of CO₂

SUBMITTER: Chan ST 

PROVIDER: S-EPMC8334185 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature