Ontology highlight
ABSTRACT:
SUBMITTER: Suh SE
PROVIDER: S-EPMC8336431 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Suh Sung-Eun SE Nkulu Leah E LE Lin Shishi S Krska Shane W SW Stahl Shannon S SS
Chemical science 20210702 30
C(sp<sup>3</sup>)-H functionalization methods provide an ideal synthetic platform for medicinal chemistry; however, such methods are often constrained by practical limitations. The present study outlines a C(sp<sup>3</sup>)-H isocyanation protocol that enables the synthesis of diverse, pharmaceutically relevant benzylic ureas in high-throughput format. The operationally simple C-H isocyanation method shows high site selectivity and good functional group tolerance, and uses commercially available ...[more]