Ontology highlight
ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC8336499 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Song Meirong M Liu Ying Y Li Tingting T Liu Xiaojia X Hao Zhihui Z Ding Shuangyang S Panichayupakaranant Pharkphoom P Zhu Kui K Shen Jianzhong J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210526 15
The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against MDR bacteria, is demonstrated. Structure-activity relationship analysis shows the prenylation modulates the activity of flavonoids and obtains two compounds, α-mangostin (AMG) and isobavachalcone (IBC ...[more]