Vesicular release dynamics are altered by the interaction between the chemical cargo and vesicle membrane lipids.

ABSTRACT: The release of the cargo from soft vesicles, an essential process for chemical delivery, is mediated by multiple factors. Among them, the regulation by the interaction between the chemical cargo species and the vesicular membrane, widely existing in all vesicles, has not been investigated to date. Yet, these interactions hold the potential to complicate the release process. We used liposomes loaded with different monoamines, dopamine (DA) and serotonin (5-HT), to simulate vesicular release and to monitor the dynamics of chemical release from isolated vesicles during vesicle impact electrochemical cytometry (VIEC). The release of DA from liposomes presents a longer release time compared to 5-HT. Modelling the release time showed that DA filled vesicles had a higher percentage of events wher

SUBMITTER: Asadpour F 

PROVIDER: S-EPMC8336585 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature