Ontology highlight
ABSTRACT:
SUBMITTER: Zheng W
PROVIDER: S-EPMC8336924 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Zheng Wei W Zhang Chengxin C Li Yang Y Pearce Robin R Bell Eric W EW Zhang Yang Y
Cell reports methods 20210621 3
Structure prediction for proteins lacking homologous templates in the Protein Data Bank (PDB) remains a significant unsolved problem. We developed a protocol, C-I-TASSER, to integrate interresidue contact maps from deep neural-network learning with the cutting-edge I-TASSER fragment assembly simulations. Large-scale benchmark tests showed that C-I-TASSER can fold more than twice the number of non-homologous proteins than the I-TASSER, which does not use contacts. When applied to a folding experi ...[more]