COSIFER: a Python package for the consensus inference of molecular interaction networks.
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ABSTRACT: Summary
The advent of high-throughput technologies has provided researchers with measurements of thousands of molecular entities and enable the investigation of the internal regulatory apparatus of the cell. However, network inference from high-throughput data is far from being a solved problem. While a plethora of different inference methods have been proposed, they often lead to non-overlapping predictions, and many of them lack user-friendly implementations to enable their broad utilization. Here, we present Consensus Interaction Network Inference Service (COSIFER), a package and a companion web-based platform to infer molecular networks from expression data using state-of-the-art consensus approaches. COSIFER includes a selection of state-of-the-art methodologies for network inference and different consensus strategies to integrate the predictions of individual methods and generate robust networks.Availability and implementation
COSIFER Python source code is available at https://github.com/PhosphorylatedRabbits/cosifer. The web service is accessible at https://ibm.biz/cosifer-aas.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Manica M
PROVIDER: S-EPMC8337002 | biostudies-literature |
REPOSITORIES: biostudies-literature
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