Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.

ABSTRACT: The antiviral property of small agonist compounds activating pattern recognition receptors (PRRs), including toll-like and RIG-I receptors, have been preclinically evaluated and are currently tested in clinical trials against chronic hepatitis B (CHB). The involvement of other PRRs in modulating hepatitis B virus infection is less known. Thus, woodchucks with resolving acute hepatitis B (AHB) after infection with woodchuck hepatitis virus (WHV) were characterized as animals with normal or delayed resolution based on their kinetics of viremia and antigenemia, and the presence and expression of various PRRs were determined in both outcomes. While PRR expression was unchanged immediately after infection, most receptors were strongly upregulated during resolution in liver but not in blood. Bes

SUBMITTER: Suresh M 

PROVIDER: S-EPMC8340647 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature