Association of NLRP3 rs35829419 and rs10754558 Polymorphisms With Risks of Autoimmune Diseases: A Systematic Review and Meta-Analysis.

ABSTRACT: The existing knowledge about the association between NLRP3 rs35829419/rs10754558 polymorphisms and susceptibility to autoimmune diseases (AIDs) remains controversial. Herein, a meta-analysis was performed to evaluate such association. We searched databases for relevant studies published in English up to February 2021. Stata14 was used to assess the odds ratio (OR). As for NLRP3 rs35829419, no significant association to overall AIDs was found in three genetic models [A vs. C: OR (95%CI) = 0.89 (0.69-1.14); AC vs. CC: 1.00 (0.77-1.30); AA/AC vs. CC: 0.93 (0.71-1.20)]. However, subgroup analysis by disease type showed that NLRP3 rs35829419 A allele may have a significant protective effect on rheumatoid arthritis (RA) susceptibility [A vs. C: 0.74 (0.57-0.96)]. NLRP3 rs10754558 polymorphism co

SUBMITTER: Wu Z 

PROVIDER: S-EPMC8340881 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature