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Prediction of gait trajectories based on the Long Short Term Memory neural networks.

ABSTRACT: The forecasting of lower limb trajectories can improve the operation of assistive devices and minimise the risk of tripping and balance loss. The aim of this work was to examine four Long Short Term Memory (LSTM) neural network architectures (Vanilla, Stacked, Bidirectional and Autoencoders) in predicting the future trajectories of lower limb kinematics, i.e. Angular Velocity (AV) and Linear Acceleration (LA). Kinematics data of foot, shank and thigh (LA and AV) were collected from 13 male and 3 female participants (28 ± 4 years old, 1.72 ± 0.07 m in height, 66 ± 10 kg in mass) who walked for 10 minutes at preferred walking speed (4.34 ± 0.43 km.h-1) and at an imposed speed (5km.h-1, 15.4% ± 7.6% faster) on a 0% gradient treadmill. The sliding window technique was adopted for training and testing the LSTM models with total kinematics time-series data of 10,500 strides. Results based on leave-one-out cross validation, suggested that the LSTM autoencoders is the top predictor of the lower limb kinematics trajectories (i.e. up to 0.1s). The normalised mean squared error was evaluated on trajectory predictions at each time-step and it obtained 2.82-5.31% for the LSTM autoencoders. The ability to predict future lower limb motions may have a wide range of applications including the design and control of bionics allowing improved human-machine interface and mitigating the risk of falls and balance loss.

SUBMITTER: Zaroug A

PROVIDER: S-EPMC8341582 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Experimental techniques for measuring chromatin accessibility are expensive and time consuming, appealing for the development of computational approaches to predict open chromatin regions from DNA sequences. Along this direction, existing methods fall into two classes: one based on handcrafted k -mer features and the other based on convolutional neural networks. Although both categories have shown good performance in specific applications thus far, there still lacks a comprehensive framework to integrate useful k -mer co-occurrence information with recent advances in deep learning.We fill this gap by addressing the problem of chromatin accessibility prediction with a convolutional Long Short-Term Memory (LSTM) network with k -mer embedding. We first split DNA sequences into k -mers and pre-train k -mer embedding vectors based on the co-occurrence matrix of k -mers by using an unsupervised representation learning approach. We then construct a supervised deep learning architecture comprised of an embedding layer, three convolutional layers and a Bidirectional LSTM (BLSTM) layer for feature learning and classification. We demonstrate that our method gains high-quality fixed-length features from variable-length sequences and consistently outperforms baseline methods. We show that k -mer embedding can effectively enhance model performance by exploring different embedding strategies. We also prove the efficacy of both the convolution and the BLSTM layers by comparing two variations of the network architecture. We confirm the robustness of our model to hyper-parameters by performing sensitivity analysis. We hope our method can eventually reinforce our understanding of employing deep learning in genomic studies and shed light on research regarding mechanisms of chromatin accessibility.The source code can be downloaded from https://github.com/minxueric/ismb2017_lstm .tingchen@tsinghua.edu.cn or ruijiang@tsinghua.edu.cn.Supplementary materials are available at Bioinformatics online.

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Prediction of gait trajectories based on the Long Short Term Memory neural networks.

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