Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis.

ABSTRACT:

Background

OPN3 upregulation associated with metastasis was recently described in two subtypes of lung cancers. And OPN3 identified in light-independent functions in epidermal melanocytes has already shown promise. However, in malignant melanocytic tissues, the expression and characterization of OPN3 remain uncharacterized.

Objectives

We investigated the clinico-histopathologic features in relation to OPN3 expression of acral lentiginous melanoma (ALM), which is a rare cutaneous melanoma subtype and not associated with prior sunlight exposure.

Methods

In all, 84 samples of junctional melanocytic nevi (JMN, n = 12), primary ALMs (n = 39) and inguinal lymph node metastasis (ILNM, n = 23) from ALMs were evaluated for the immunohistochemical expression of OPN3. OPN3 messe

SUBMITTER: Zeng W 

PROVIDER: S-EPMC8342238 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature