Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma Receiving Transarterial Chemoembolization.

ABSTRACT:

Purpose

The purpose of this study was to investigate the predictive capability of neutrophil-to-apolipoprotein A1 ratio (NAR) for predicting overall survival (OS) among patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE).

Patients and methods

We investigated the clinical features of 554 patients with HCC receiving TACE and assessed NAR's predictive value for OS with 222 patients (the discovery cohort) and 332 patients (the validation cohort). The association of NAR with circulation lectin-type oxidized low-density lipoprotein receptor-1-positive (LOX-1⁺ ) polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) was illustrated.

Results

Multivariate Cox regression revealed that lymphocyte count; Tumor, Node, Me

SUBMITTER: Chen J 

PROVIDER: S-EPMC8342583 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature