Predicting Protein-Protein Interactions Between Rice and Blast Fungus Using Structure-Based Approaches.

ABSTRACT: Rice blast, caused by the fungus Magnaporthe oryzae, is the most devastating disease affecting rice production. Identification of protein-protein interactions (PPIs) is a critical step toward understanding the molecular mechanisms underlying resistance to blast fungus in rice. In this study, we presented a computational framework for predicting plant-pathogen PPIs based on structural information. Compared with the sequence-based methods, the structure-based approach showed to be more powerful in discovering new PPIs between plants and pathogens. Using the structure-based method, we generated a global PPI network consisted of 2,018 interacting protein pairs involving 1,344 rice proteins and 418 blast fungus proteins. The network analysis showed that blast resistance genes were enrich

SUBMITTER: Zheng C 

PROVIDER: S-EPMC8343130 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature