Shifting sands: the role of radiotherapy for patients with gastric and gastroesophageal adenocarcinoma.

ABSTRACT: Gastric adenocarcinoma, a leading cause of cancer-related mortality worldwide, is treated primarily with surgical resection in the non-metastatic setting. However, the optimal role and sequencing of adjunctive therapies, including radiotherapy (RT) as well as systemic therapy, remains unclear. A complex milieu of trials spanning several decades has evaluated different treatment strategies for gastric cancer, including the role of RT. In this review, we summarize the trial-level evidence for the diverse gastric cancer treatment paradigms. Despite initial success, postoperative RT has not shown a clear benefit in modern prospective studies in the setting of more aggressive surgical nodal dissection. On the other hand, the role of preoperative RT in optimizing oncologic outcomes for gastric c

SUBMITTER: Ludmir EB 

PROVIDER: S-EPMC8343419 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature