Hepatocellular Carcinoma Immunotherapy and the Potential Influence of Gut Microbiome.

ABSTRACT: Disruptions in the human gut microbiome have been associated with a cycle of hepatocyte injury and regeneration characteristic of chronic liver disease. Evidence suggests that the gut microbiota can promote the development of hepatocellular carcinoma through the persistence of this inflammation by inducing genetic and epigenetic changes leading to cancer. As the gut microbiome is known for its effect on host metabolism and immune response, it comes as no surprise that the gut microbiome may have a role in the response to therapeutic strategies such as immunotherapy and chemotherapy for liver cancer. Gut microbiota may influence the efficacy of immunotherapy by regulating the responses to immune checkpoint inhibitors in patients with hepatocellular carcinoma. Here, we review the mechanisms

SUBMITTER: Temraz S 

PROVIDER: S-EPMC8346024 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature