Association of Thrombosis With Hypereosinophilic Syndrome in Patients With Genetic Alterations.

ABSTRACT:

Importance

Hypereosinophilic syndromes (HESs) are a rare group of disorders that result in overproduction of eosinophils, leading to tissue damage. Thrombotic complications in HES and associated risk factors in this patient population have not been extensively studied.

Objective

To investigate the rates of and risk factors associated with thrombotic events in patients with HES, including markers of clonal hematopoiesis as evidenced by molecular aberrations on next-generation sequencing.

Design, setting, and participants

This retrospective cohort study evaluated patients seen at Brigham and Women's Hospital and Harvard Medical School in Boston, Massachusetts, from January 1, 2015, to January 1, 2020. Patients who had hypereosinophilia with an absolute eosinophil count

SUBMITTER: Leiva O 

PROVIDER: S-EPMC8346937 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature