Effect of Vasoactive Intestinal Polypeptide on Development of Migraine Headaches: A Randomized Clinical Trial.

ABSTRACT:

Importance

Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) are structurally and functionally related, yet different in their migraine-inducing properties. It remains unclear whether the lack of migraine induction can be attributed to the only transient vasodilatory response after a 20-minute infusion of VIP.

Objective

To determine whether a 2-hour infusion of VIP would provoke migraine attacks.

Design, setting, and participants

A randomized, double-blind, placebo-controlled, crossover study was conducted between May and September 2020 at the Danish Headache Center in Copenhagen, Denmark. Patients were eligible for inclusion if they were ages 18 to 40 years, weighed between 50 and 90 kg, had a diagnosis of migrai

SUBMITTER: Pellesi L 

PROVIDER: S-EPMC8346940 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature