Ontology highlight
ABSTRACT:
SUBMITTER: Jacquet P
PROVIDER: S-EPMC8347808 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Jacquet Pauline P Rémy Benjamin B Bross Rowdy P T RPT van Grol Marco M Gaucher Floriane F Chabrière Eric E de Koning Martijn C MC Daudé David D
International journal of molecular sciences 20210729 15
Organophosphorus nerve agents (OPNAs) are highly toxic compounds inhibiting cholinergic enzymes in the central and autonomic nervous systems and neuromuscular junctions, causing severe intoxications in humans. Medical countermeasures and efficient decontamination solutions are needed to counteract the toxicity of a wide spectrum of harmful OPNAs including G, V and Novichok agents. Here, we describe the use of engineered OPNA-degrading enzymes for the degradation of various toxic agents including ...[more]