Implikationen fur Lehre, Praxis und Wissenschaft
Ontology highlight
ABSTRACT:
SUBMITTER: Graf J
PROVIDER: S-EPMC8349612 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Introduction: The German DRG system is annually adapted to the changing services provided. For the further development, the self-governing body and its DRG Institute (InEK) depend on participation of the users. Methods: For one of the DRG evaluation projects initiated by DGGG, cost and performance data for the year 2011 from 16 hospitals were available. After plausibility checks and corrections, analyses for service and cost homogeneity were performed. In cases of inadequate DRG-representation attributes were sought that would make an appropriate reimbursement possible. Conspicuities and potential solutions were checked for clinical plausibility. Results: 44 concrete modification proposals for further development of the G-DRG system were formulated and submitted in due time to the InEK. In addition, 3 modification proposals were addressed to the German Institute for Medical Documentation and Information (Deutsches Institut für Medizinische Dokumentation und Information, DIMDI) for further development of the diagnosis classification ICD-10-GM. For all modification proposals care was taken to minimise misdirected incentives and to reduce the potential for disputes with the cost bearers and their auditors services in settlements. Discussion: The publication of the G-DRG system 2014 shows which modification proposals have been realised. Essentially, an appropriate redistribution of the resources among the gynaecological and obstetrics departments is to be expected. The financial pressure that is caused by the generally inadequate financing of hospitals will not be reduced by a further development of the G-DRG system.
| S-EPMC3858986 | biostudies-literature
Project description:Translation abstract Since students are often very susceptible to misinformation, (out‐of‐)school formats are needed that make it possible to identify fake news. For this reason, a total of five science communication formats were developed, which are dedicated to the topic of “Fake News in the Corona Pandemic”. These include, for example, a student lab setting and an innovative book. The formats can be seen as a supplement to chemistry lessons and enable the students to increase their competence. This article also presents two of the 13 experiments from the student lab setting and the book, which can also be used in chemistry lessons.
| S-EPMC9086986 | biostudies-literature
Project description:Zusammenfassung Die Adipositas ist eine über das Normalmaß hinausgehende Vermehrung des Körperfetts und wird über den Body-Mass- Index (BMI = kg/m) bestimmt. Ab einem BMI von 30 kg/m liegt definitionsgemäß eine Adipositas vor. Der Krankheitswert ergibt sich aus der Assoziation von Folgeerkrankungen, deren Risiko mit der Prävalenzdauer und dem Schweregrad der Adipositas ansteigt (Tab. 28.1). Dabei korreliert das kardiovaskuläre Risiko besonders mit dem Vorliegen einer viszeralen Adipositas (>88/102 cm Taillenumfang bei Frauen/ Männern). Die Prävalenz der Adipositas steigt in Deutschland kontinuierlich an. Derzeit ist knapp ein Viertel der deutschen Bevölkerung als adipös einzustufen.
| S-EPMC7121273 | biostudies-literature
Project description:Zur Analyse abgeatmeter Gase muss endexspiratorische Luft gewonnen werden, ohne Vermischung mit frühexspiratorischer Luft (sonst Korrektur mit Messung des CO2-Partialdrucks, s. unten). Ältere Kinder blasen nach Anhalten der Atmung über 15 s durch tiefe Ausatmung über einen Strohhalm endexspiratorische Luft in ein Glasröhrchen, das dann luftdicht verschlossen wird (Vacutainer), oder über ein Mundstück oder eine Maske direkt in ein H2-Messgerät oder in Beutel. Bei Säuglingen und Kleinkindern kann mit einer Maske oder einer Sonde, die bis zum nasopharyngealen Übergang vorgeschoben wird, mit einer Spritze atemsynchron exspiratorische Luft abgesaugt und in Vacutainer oder direkt in das Messgerät eingegeben werden. In Vacutainern sind Proben über mehr als 30 Tage stabil und können auch zur Analyse verschickt werden.
| S-EPMC7498812 | biostudies-literature
Project description:Ein modernes „case-based“ E‑Learning ist ein exzellentes Hilfsmittel, um Skills und Kommunikation zu trainieren, da „diagnostic reasoning“ als schematisches Problemlösen gesehen wird. Wir präsentieren einen Patientenfall zum Thema Gerinnungsstörung bei chronischem Substanzmissbrauch, bei dem nur durch interdisziplinäres Vorgehen ein adäquater Erfolg erzielt werden kann. Diesbezüglich ist zu erwähnen, dass zu diesem Thema noch wenig Evidenz vorhanden ist und es noch weiterer Forschung bedarf. Zusatzmaterial online In der Online-Version dieses Artikels (10.1007/s00739-020-00655-3) finden Sie weiterführende Literatur zum Thema.
| S-EPMC7330881 | biostudies-literature
Project description:Global tranascriptional profiling of Bacillus subtilis cells comparing fur mutant to mutants of the iron-sparing response: fur fsrA double mutant, fur fbpAB triple mutant, fur fbpC double mutant, and fur fbpABC quadruple mutant Abstract of associated manuscript: The Bacillus subtilis ferric uptake regulator (Fur) protein is the major sensor of cellular iron status. When iron is limiting for growth, derepression of the Fur regulon increases the cellular capacity for iron uptake and mobilizes an iron-sparing response mediated, in large part, by a small non-coding RNA named FsrA. FsrA functions together with three small, basic proteins (FbpABC) to repress many "low-priority" iron-containing enzymes. We have used transcriptome analyses to define the scope of the iron-sparing response and to define subsets of genes dependent on either FbpAB or FbpC for their repression. Enzymes of the tricarboxylic acid cycle, including both aconitase and succinate dehydrogenase, are major targets of FsrA-mediated repression and, as a consequence, flux through this pathway is significantly decreased under iron limitation. FsrA also mediates a physiologically significant repression of iron-sulfur containing enzymes required for ammonium assimilation (the GltAB glutamate synthase) and catabolism of lactic acid (LutABC). Repression of the lutABC operon requires both FsrA and FbpB which supports a model in which the Fbp proteins function to enable repression of subsets of the FsrA regulon.
2011-02-19 | GSE27416 | GEO
Project description:Global transcriptional profiling of Bacillus subtilis cells comparing fur mutant to mutants of the iron-sparing response: fur fsrA double mutant, fur fbpAB triple mutant, fur fbpC double mutant, and fur fbpABC quadruple mutant fur vs fur fsrA (fsrA), fur vs fur fbpAB (AB), fur vs fur fbpC (C), and fur vs fur fbpABC (ABC). Each experiemnt (fur vs mutant) was conducted three times using three independent total RNA preparations (2 independent experiement + 1 independent dye swap).
2011-02-19 | E-GEOD-27416 | biostudies-arrayexpress
Project description:On account of the current low interest rate phase, which is most likely to continue in the coming years, the average yields to be achieved in the bond, time deposit and savings product sectors are declining, so that risk-averse investors in particular have few opportunities to generate return-oriented retirement provisions. This scientific article analyzes the level of a possible safe withdrawal rate for diversified pension portfolios, considering historical returns and inflation rates. Consequently, this article provides immediate practical added value for a possible retirement provision. The evaluation is based on the consideration of historical returns of the stock and bond market in Germany. To determine a safe withdrawal rate, the development of portfolios with different compositions and inflation-adjusted withdrawal rates are simulated over periods of 15 to 35 years. In this simulation, the risky part of the portfolio is represented by German equities, the low risk part by German government bonds. To sum up, the empirical results show a maximum safe withdrawal rate of 4%. The underlying portfolio is composed of 50% equities and 50% government bonds. Particularly due to the outlined demographic change in Germany as well as the ongoing low-interest phase, the empirical study can provide significant theoretical and practical insights. Supplementary Information The online version of this article (10.1007/s12297-021-00504-1) contains supplementary material, which is available to authorized users.
| S-EPMC8475470 | biostudies-literature
Project description:The prenyl fragment is the quintessential constituent of terpenoid natural products, a diverse family which contains numerous members with diverse biological properties. In contrast, fluorinated and multifluorinated arenes make up an important class of anthropogenic molecules which are highly relevant to material, agricultural, and pharmaceutical industries. While allylation chemistry is well developed, effective prenylation strategies have been less forthcoming. Herein, we describe the photocatalytic defluoroprenylation, a powerful method that provides access to "hybrid molecules" that possess both the functionality of a prenyl group and fluorinated arenes. This approach involves direct prenyl group transfer under very mild conditions, displays excellent functional group tolerance, and includes relatively short reaction times (<4 h), which is the fastest photocatalytic C-F functionalization developed to date. Additionally, the strategy can be extended to include allyl and geranyl (10 carbon fragment) transfers. Another prominent finding is a reagent-dependent switch in regioselectivity of the major product from para to ortho C-F functionalization.
| S-EPMC6581450 | biostudies-literature
Project description:Transactive knowledge systems and psychological safety are important requirements for the effective functioning of organisations. However, both constructs have not yet been discussed in conjunction. This contribution presents both constructs and develops a theoretical approach that allows both further empirical exploration and practical application. Several propositions are made that intend to foster the further development of empirical study and related theory. Supplementary Information The online version of this article (10.1007/s11613-021-00722-7) contains supplementary material, which is available to authorized users.
| S-EPMC8356548 | biostudies-literature