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The RagA and RagB proteins of Porphyromonas gingivalis.


ABSTRACT: RagA and RagB proteins are major components of the outer membrane of the oral pathogen Porphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that the rag locus contributes to P. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag-focused therapeutic strategies for the control of periodontal diseases.

SUBMITTER: Potempa J 

PROVIDER: S-EPMC8349833 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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The RagA and RagB proteins of Porphyromonas gingivalis.

Potempa Jan J   Madej Mariusz M   Scott David A DA  

Molecular oral microbiology 20210608 4


RagA and RagB proteins are major components of the outer membrane of the oral pathogen Porphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that the rag locus contributes to P. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to  ...[more]

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