Urinary Biomarkers and Kidney Outcomes: Impact of Indexing Versus Adjusting for Urinary Creatinine.

ABSTRACT:

Rationale & objective

Urinary biomarker concentrations are frequently indexed to urinary creatinine (Ucr) concentration in spot samples to account for urine dilution; however, this may introduce biases. We evaluated whether indexing versus adjusting urinary biomarker concentrations for Ucr concentration altered their associations with outcomes.

Study design

Observational cohort.

Setting & participants

We analyzed data from 2,360 Systolic Blood Pressure Intervention Trial (SPRINT) participants with estimated glomerular filtration rates < 60 mL/min/1.73 m² and urinary albumin (UAlb) and 8 urinary kidney tubule biomarkers measured at baseline.

Outcomes

The primary outcome was a composite of cardiovascular disease events; secondary outcomes were all-caus

SUBMITTER: Wettersten N 

PROVIDER: S-EPMC8350828 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature