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Electrochemical Decarboxylative N-Alkylation of Heterocycles.


ABSTRACT: An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.

SUBMITTER: Sheng T 

PROVIDER: S-EPMC8350983 | biostudies-literature |

REPOSITORIES: biostudies-literature

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