Electrochemical Decarboxylative N-Alkylation of Heterocycles.
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ABSTRACT: An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.
SUBMITTER: Sheng T
PROVIDER: S-EPMC8350983 | biostudies-literature |
REPOSITORIES: biostudies-literature
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