Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia.

ABSTRACT:

Background

Aberrant angiogenesis may play a role in the development of Alzheimer's disease and related dementia.

Objective

To explore the relationship between angiogenesis activity and evidence of neurodegeneration among older adults.

Methods

Cross-sectional study of 49 older adults clinically characterized as cognitively normal, mild cognitive impairment, or early Alzheimer's disease. In addition to neuroimaging, we completed assays on peripheral blood, including: vascular endothelial growth factor, tumor necrosis factor, fibroblast growth factor, and amyloid-β peptide 40. We used advanced polychromatic flow cytometry to phenotype circulating mononuclear cells to assess angiogenesis activity.

Results

Although we documented differences in cognitive performance,

SUBMITTER: Callahan CM 

PROVIDER: S-EPMC8351220 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature