Ontology highlight
ABSTRACT:
SUBMITTER: Kang Y
PROVIDER: S-EPMC8351399 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Kang Yeona Y Pandya Sneha S Zinger Nicole N Michaelson Nara N Gauthier Susan A SA
Annals of clinical and translational neurology 20210726 8
The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET. Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 ...[more]