Short-Term Tolerability, Safety, and Gut Microbial Composition Responses to a Multi-Strain Probiotic Supplement: An Open-Label Study in Healthy Adults.

ABSTRACT:

Background

Probiotics are among the most commonly used dietary supplements and evidence of their efficacy is increasing. Despite the long historical use of probiotics, some experts suggest that additional research is necessary to understand their potential risks.

Objectives

Main aims of this study were to assess short-term tolerability and safety of a new, high colony-forming unit count, multi-strain probiotic supplement. Exploratory objectives included evaluating effects on gut microbial composition.

Methods

Ten healthy adults were enrolled in a single-arm, open-label study. Over a 10-day period, participants consumed a once daily probiotic capsule (2.1 x 10¹¹ CFU) containing Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37,

SUBMITTER: Ryan JJ 

PROVIDER: S-EPMC8352413 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature