Ontology highlight
ABSTRACT:
SUBMITTER: Hummel JJA
PROVIDER: S-EPMC8353518 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Hummel Jessica J A JJA Hoogenraad Casper C CC
Journal of cell science 20210803 15
Molecular motors drive long-range intracellular transport of various vesicles and other cargoes within a cell. Identifying which kinesin motors interact with which type of transport vesicles has been challenging, especially in complex neuronal cells. Here, we present a highly adaptable toolbox of engineered kinesin motors to control and interrogate the selectivity and regulation of cargo transport with acute chemical induction. Selectivity of cargo-motor interaction can be addressed by systemati ...[more]