Detection of Leptomeningeal Disease Using Cell-Free DNA From Cerebrospinal Fluid.

ABSTRACT:

Importance

Leptomeningeal disease (LMD) is a devastating complication of cancer that is frequently underdiagnosed owing to the low sensitivity of cerebrospinal fluid (CSF) cytologic assessment, the current benchmark diagnostic method. Improving diagnostic sensitivity may lead to improved treatment decisions.

Objective

To assess whether cell-free DNA (cfDNA) analysis of CSF may be used to diagnose LMD more accurately than cytologic analysis.

Design, setting, and participants

This diagnostic study conducted in a neuro-oncology clinic at 2 large, tertiary medical centers assessed the use of genomic sequencing of CSF samples obtained from 30 patients with suspected or confirmed LMD from 2015 through 2018 to identify tumor-derived cfDNA. From the same CSF samples, cytologi

SUBMITTER: White MD 

PROVIDER: S-EPMC8353541 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature