Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC8353630 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Wang Dinghai D Jana Kalipada K Studer Armido A
Organic letters 20210714 15
Radical α-C-H functionalization of alk-5-enyl boronic esters with concomitant functionalization of the alkene moiety is reported. These cascades comprise perfluoroalkyl radical addition to the alkene moiety of a boronate complex, intramolecular hydrogen atom transfer (HAT), single electron oxidation, and 1,2-alkyl/aryl migration. The boronate complexes are readily generated in situ by reaction of the alkenyl boronic esters with alkyl or aryl lithium reagents. Products are formed in a divergent a ...[more]