Unknown

Dataset Information

0

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.

ABSTRACT: Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03-0.33) and positive (B = 0.19; 95%CI 0.03-0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11-0.52) and in controls (B = 0.26; 95%CI 0.06-0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.

SUBMITTER: Quattrone D 

PROVIDER: S-EPMC8355107 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.

Quattrone Diego D   Reininghaus Ulrich U   Richards Alex L AL   Tripoli Giada G   Ferraro Laura L   Quattrone Andrea A   Marino Paolo P   Rodriguez Victoria V   Spinazzola Edoardo E   Gayer-Anderson Charlotte C   Jongsma Hannah E HE   Jones Peter B PB   La Cascia Caterina C   La Barbera Daniele D   Tarricone Ilaria I   Bonora Elena E   Tosato Sarah S   Lasalvia Antonio A   Szöke Andrei A   Arango Celso C   Bernardo Miquel M   Bobes Julio J   Del Ben Cristina Marta CM   Menezes Paulo Rossi PR   Llorca Pierre-Michel PM   Santos Jose Luis JL   Sanjuán Julio J   Arrojo Manuel M   Tortelli Andrea A   Velthorst Eva E   Berendsen Steven S   de Haan Lieuwe L   Rutten Bart P F BPF   Lynskey Michael T MT   Freeman Tom P TP   Kirkbride James B JB   Sham Pak C PC   O'Donovan Michael C MC   Cardno Alastair G AG   Vassos Evangelos E   van Os Jim J   Morgan Craig C   Murray Robin M RM   Lewis Cathryn M CM   Di Forti Marta M  

Translational psychiatry 20210810 1

Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associ  ...[more]

Similar Datasets

Unknown Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study.
| S-EPMC6518388 | biostudies-literature
Unknown The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study.
| S-EPMC8473991 | biostudies-literature
Unknown Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study.
| S-EPMC10106300 | biostudies-literature
Unknown Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study.
| S-EPMC10719680 | biostudies-literature
Unknown Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: the EU-GEI case-control study.
| S-EPMC8223239 | biostudies-literature
Unknown Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.
| S-EPMC10277719 | biostudies-literature
Unknown Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study.
| S-EPMC10520604 | biostudies-literature
Unknown First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.
| S-EPMC9810012 | biostudies-literature
Unknown Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case-control study.
| S-EPMC8311819 | biostudies-literature
Unknown Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI).
| S-EPMC9077421 | biostudies-literature