Ontology highlight
ABSTRACT:
SUBMITTER: Na D
PROVIDER: S-EPMC8355375 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Na Deukchae D Chae Jeesoo J Cho Sung-Yup SY Kang Wonyoung W Lee Ahra A Min Seoyeon S Kang Jinjoo J Kim Min Jung MJ Choi Jaeyong J Lee Woochan W Shin Dongjin D Min Ahrum A Kim Yu-Jin YJ Lee Kyung-Hun KH Kim Tae-Yong TY Suh Yun-Suhk YS Kong Seong-Ho SH Lee Hyuk-Joon HJ Kim Woo-Ho WH Park Hansoo H Im Seock-Ah SA Yang Han-Kwang HK Lee Charles C Kim Jong-Il JI
Nature communications 20210810 1
Gastric cancer (GC) is commonly treated by chemotherapy using 5-fluorouracil (5-FU) derivatives and platinum combination, but predictive biomarker remains lacking. We develop patient-derived xenografts (PDXs) from 31 GC patients and treat with a combination of 5-FU and oxaliplatin, to determine biomarkers associated with responsiveness. When the PDXs are defined as either responders or non-responders according to tumor volume change after treatment, the responsiveness of PDXs is significantly co ...[more]