Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection.
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ABSTRACT: Background
Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection.Methods
Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed.Results
WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir.Conclusions
Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.
SUBMITTER: Sherman AC
PROVIDER: S-EPMC8355461 | biostudies-literature |
REPOSITORIES: biostudies-literature
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