Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC8355706 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Wu Qiong Q Liu Tian-Yi TY Hu Bai-Chun BC Li Xiang X Wu Yu-Ting YT Sun Xiao-Tong XT Jiang Xiao-Wen XW Wang Shu S Qin Xiao-Chun XC Ding Huai-Wei HW Zhao Qing-Chun QC
Frontiers in oncology 20210728
Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor prognosis that highly expresses phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (ERK). The PI3K/AKT/mTOR and MAPK/ERK signaling pathways play a crucial role in HCC tumor formation, cell cycle, apoptosis and survival. However, no effective targeted therapies against these pathways is available, mainly due to the extensive and complex negative feedback loops between them. Here we used CK-3, a dual blocker o ...[more]