Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents.

ABSTRACT:

Background and purpose

Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse. However, an alternative approach to existing analgesics is to indirectly increase endogenous pain relief pathways by neprilysin (an enkephalinase) inhibitors. This enzyme breaks down and inactivates enkephalin, dynorphin, endorphins, and their derivatives.

Experimental approach

In this project, a new series of racecadotril-tetrazole-amino acid derivatives 15a-l was synthesized and characterized on the basis of IR, ¹H and ¹³C NMR, mass spectrometry, and elemental analysis. The antinociceptive activity of synthesized compounds was

SUBMITTER: Asadi M 

PROVIDER: S-EPMC8356715 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature