Determinants of response and mechanisms of resistance of CAR T-cell therapy in multiple myeloma.

ABSTRACT: BCMA-specific CAR T-cells have substantial therapeutic potential in multiple myeloma (MM), but most patients eventually relapse. Determinants of response and mechanisms of resistance are most likely multifactorial and include MM-related factors, premanufacturing T-cell characteristics, CAR T-cell-related features, and several components of the immunosuppressive microenvironment. Efforts to improve the potency and safety of CAR T-cell therapy include optimizing CAR design, combinatorial approaches to enhance persistence and activity, treatment of less heavily pretreated patients, and dual-antigen targeting to prevent antigen escape. We expect that these rationally designed strategies will contribute to further improvement in the clinical outcome of MM patients.

SUBMITTER: van de Donk NWCJ 

PROVIDER: S-EPMC8357299 | biostudies-literature |

REPOSITORIES: biostudies-literature