Ontology highlight
ABSTRACT:
SUBMITTER: Gao F
PROVIDER: S-EPMC8357496 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Gao Feng F Liu Guozhong G Wang Jingwen J Huang Shirong S Ding Fadian F Lian Wei W Lv Xiaoting X Guo Yujia Y Fan Xiangqun X Zhang Sheng S Liu Qicai Q
Oxidative medicine and cellular longevity 20210803
Calcitonin gene-related peptide (CGRP) plays a diverse and intricate role in chronic low-grade inflammation and is closely related to specific cancers. It includes two subtypes, CALCA (<i>α</i>CGRP) and CALCB (<i>β</i>CGRP), of which <i>α</i>CGRP expression accounts for more than 90%. Here, we show that methylation of CALCA and CALCB in pancreatic ductal adenocarcinoma was significantly higher than that in paracancer. Western blot and immunohistochemistry showed that CGRP, p-AKT, and p-CREB in t ...[more]