Rewiring of the ubiquitinated proteome determines ageing in C. elegans.

ABSTRACT: Ageing is driven by a loss of cellular integrity¹. Given the major role of ubiquitin modifications in cell function², here we assess the link between ubiquitination and ageing by quantifying whole-proteome ubiquitin signatures in Caenorhabditis elegans. We find a remodelling of the ubiquitinated proteome during ageing, which is ameliorated by longevity paradigms such as dietary restriction and reduced insulin signalling. Notably, ageing causes a global loss of ubiquitination that is triggered by increased deubiquitinase activity. Because ubiquitination can tag proteins for recognition by the proteasome³, a fundamental question is whether deficits in targeted degradation influence longevity. By integrating data from worms with a defective proteasome, we iden

SUBMITTER: Koyuncu S 

PROVIDER: S-EPMC8357631 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature