Ontology highlight
ABSTRACT:
SUBMITTER: Nazio F
PROVIDER: S-EPMC8357694 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Nazio Francesca F Po Agnese A Abballe Luana L Ballabio Claudio C Diomedi Camassei Francesca F Bordi Matteo M Camera Antonio A Caruso Simona S Caruana Ignazio I Pezzullo Marco M Ferraina Caterina C Milletti Giacomo G Gianesello Matteo M Reddel Sofia S De Luca Carmen Dolores CD Ceglie Donatella D Marinelli Sara S Campello Silvia S Papaleo Elena E Miele Evelina E Cacchione Antonella A Carai Andrea A Vinci Maria M Velardi Enrico E De Angelis Biagio B Tiberi Luca L Quintarelli Concetta C Mastronuzzi Angela A Ferretti Elisabetta E Locatelli Franco F Cecconi Francesco F
Acta neuropathologica 20210724 3
Medulloblastoma (MB) is a childhood malignant brain tumour comprising four main subgroups characterized by different genetic alterations and rate of mortality. Among MB subgroups, patients with enhanced levels of the c-MYC oncogene (MB<sub>Group3</sub>) have the poorest prognosis. Here we identify a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating MB. We demonstrate that AMBRA1 expression depends on c-MYC levels and correlates with Group 3 patient poor prognosis; als ...[more]