Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations.
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ABSTRACT:
SUBMITTER: Strazar M
PROVIDER: S-EPMC8357928 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations.
Stražar Martin M Temba Godfrey S GS Vlamakis Hera H Kullaya Vesla I VI Lyamuya Furaha F Mmbaga Blandina T BT Joosten Leo A B LAB van der Ven Andre J A M AJAM Netea Mihai G MG de Mast Quirijn Q Xavier Ramnik J RJ
Nature communications 20210811 1
The human gut microbiota is increasingly recognized as an important factor in modulating innate and adaptive immunity through release of ligands and metabolites that translocate into circulation. Urbanizing African populations harbor large intestinal diversity due to a range of lifestyles, providing the necessary variation to gauge immunomodulatory factors. Here, we uncover a gradient of intestinal microbial compositions from rural through urban Tanzanian, towards European samples, manifested bo ...[more]
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