Ontology highlight
ABSTRACT:
SUBMITTER: Tesch F
PROVIDER: S-EPMC8358871 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Tesch Florian F Siegerist Florian F Hay Eleonora E Artelt Nadine N Daniel Christoph C Amann Kerstin K Zimmermann Uwe U Kavvadas Panagiotis P Grisk Olaf O Chadjichristos Christos C Endlich Karlhans K Chatziantoniou Christos C Endlich Nicole N
Journal of cellular and molecular medicine 20210622 16
Under healthy conditions, foot processes of neighbouring podocytes are interdigitating and connected by an electron-dense slit diaphragm. Besides slit diaphragm proteins, typical adherens junction proteins are also found to be expressed at this cell-cell junction. It is therefore considered as a highly specialized type of adherens junction. During podocyte injury, podocyte foot processes lose their characteristic 3D structure and the filtration slits typical meandering structure gets linearized. ...[more]