Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.

ABSTRACT:

Introduction

Individuals in early dementia prevention trials may differ in how much they benefit from interventions depending on their initial risk level. Additionally, modifiable dementia risk scores might be used as surrogate/intermediate outcomes.

Methods

In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated in post hoc analyses (N = 1207) whether the cognitive benefits of the 2-year multi-domain lifestyle intervention differed by baseline dementia risk measured with the "LIfestyle for BRAin Health" (LIBRA) score. We also investigated intervention effects on change in LIBRA score over time.

Results

Overall, higher baseline LIBRA was related to less cognitive improvement over time. This association did n

SUBMITTER: Deckers K 

PROVIDER: S-EPMC8359273 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature