Ontology highlight
ABSTRACT:
SUBMITTER: Maleki R
PROVIDER: S-EPMC8359851 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Maleki Reza R Khedri Mohammad M Rezvantalab Sima S Afsharchi Fatemeh F Musaie Kiyan K Shafiee Sepehr S Shahbazi Mohammad-Ali MA
Chembiochem : a European journal of chemical biology 20210511 13
Cytotoxic aggregation of misfolded β-amyloid (Aβ) proteins is the main culprit suspected to be behind the development of Alzheimer's disease (AD). In this study, Aβ interactions with the novel two-dimensional (2D) covalent organic frameworks (COFs) as therapeutic options for avoiding β-amyloid aggregation have been investigated. The results from multi-scale atomistic simulations suggest that amine-functionalized COFs with a large surface area (more than 1000 m<sup>2</sup> /gr) have the potential ...[more]