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Adipocyte NR1D1 dictates adipose tissue expansion during obesity.

ABSTRACT: The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observed under adipocyte-selective deletion (Nr1d1^Flox2-6:Adipoq^Cre), and transcriptional profiling demonstrates that, under basal conditions, direct targets of NR1D1 regulation are limited, and include the circadian clock and collagen dynamics. Under high-fat diet (HFD) feeding, Nr1d1^Flox2-6:Adipoq^Cre mice do manifest profound obesity, yet without the accompanying WAT inflammation and fibrosis exhibited by controls. Integration of the WAT NR1D1 cistrome with differential gene expression reveals broad control of metabolic processes by NR1D1 which is unmasked in the obese state. Adipocyte NR1D1 does not drive an anticipatory daily rhythm in WAT lipogenesis, but rather modulates WAT activity in response to alterations in metabolic state. Importantly, NR1D1 action in adipocytes is critical to the development of obesity-related WAT pathology and insulin resistance.

SUBMITTER: Hunter AL

PROVIDER: S-EPMC8360653 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

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Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

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Adipose Precursor HO-1 determines healthy visceral adipose tissue expansion during obesity

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-03-08 | GSE80148 | GEO

Adipose Precursor HO-1 prevents healthy visceral adipose tissue expansion during obesity[II]

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2017-03-08 | GSE80147 | GEO

Adipose Precursor HO-1 prevents healthy visceral adipose tissue expansion during obesity [I]

2017-03-08 | GSE80146 | GEO

Grape Seed Proanthocyanidins Improve White Adipose Tissue Expansion during Diet-Induced Obesity Development in Rats.

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Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion.

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| S-EPMC7384517 | biostudies-literature

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| S-EPMC4793714 | biostudies-literature

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