Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study.

ABSTRACT:

Aims

Diabetes is recognized as the leading cause of chronic kidney disease (CKD); however, the association of prediabetes with CKD remains unclear, in particular, the independent effect of prediabetes on proteinuria or estimated glomerular filtration rate (eGFR) has not been evaluated. This study aimed to investigate the associations of prediabetes with the proteinuria development and with eGFR decline separately in the Japanese general population without CKD.

Methods

Participants who underwent health check-ups in 2014 and had adequate data after 2 years were retrospectively analysed. A total of 405,487 participants without CKD (eGFR, ≥60 ml min^-1  1.73 m^-2 , with negative or trace urinary protein) at baseline were categorized according to fasting plasm

SUBMITTER: Furukawa M 

PROVIDER: S-EPMC8361992 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature