Autism with dysphasia accompanied by mental retardation caused by FOXP1 exon deletion: A case report.

ABSTRACT:

Background

Forkhead box protein 1 (FOXP1) (OMIM: 605515) at chromosomal region 3p14.1 plays an important regulatory role in cell development and functions by regulating genetic expression. Earlier studies have suggested that FOXP1, an oncogene, is capable of initiating tumorigenicity depending on the cell type. FOXP1 also plays an important role in regulating the cell development and functions of the immune system, e.g., regulating B-cell maturation and mononuclear phagocyte differentiation, and in the occurrence and development of various immune diseases. The mRNA of this gene is widely expressed in humans, and its differential expression is related to numerous diseases.

Case summary

A 5-year-old boy mainly presented with attention deficit and hy

SUBMITTER: Lin SZ 

PROVIDER: S-EPMC8362507 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature