Alpha emitting nuclides for targeted therapy.

ABSTRACT: Targeted alpha therapy (TAT) is an area of research with rapidly increasing importance as the emitted alpha particle has a significant effect on inducing cytotoxic effects on tumor cells while mitigating dose to normal tissues. Two significant isotopes of interest within the area of TAT are thorium-227 and actinium-225 due to their nuclear characteristics. Both isotopes have physical half-lives suitable for coordination with larger biomolecules, and additionally actinium-225 has potential to serve as an in vivo generator. In this review, the authors will discuss the production, purification, labeling reactions, and biological studies of actinium-225 and thorium-227 complexes and clinical studies.

SUBMITTER: Hatcher-Lamarre JL 

PROVIDER: S-EPMC8363053 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature