Photoinduced copper-catalysed asymmetric amidation via ligand cooperativity.

ABSTRACT: The substitution of an alkyl electrophile by a nucleophile is a foundational reaction in organic chemistry that enables the efficient and convergent synthesis of organic molecules. Although there has been substantial recent progress in exploiting transition-metal catalysis to expand the scope of nucleophilic substitution reactions to include carbon nucleophiles^1-4, there has been limited progress in corresponding reactions with nitrogen nucleophiles^5-8. For many substitution reactions, the bond construction itself is not the only challenge, as there is a need to control stereochemistry at the same time. Here we describe a method for the enantioconvergent substitution of unactivated racemic alkyl electrophiles by a ubiquitous nitrogen-containing functional group, an am

SUBMITTER: Chen C 

PROVIDER: S-EPMC8363576 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature