Dataset Information

Three-Dimensional Reconstruction and Swept-Source Optical Coherence Tomography for Crystalline Lens Tilt and Decentration Relative to the Corneal Vertex.

ABSTRACT:

Purpose

To investigate crystalline lens tilt and decentration with respect to the corneal vertex (CV) using swept-source optical coherence tomography (SS-OCT) combined with three-dimensional (3D) reconstruction.

Methods

Thirty consecutive patients with cataract (30 right eyes) were included in this prospective, observational, pilot case series study. SS-OCT anterior segment images and 3D reconstructions were used for data analysis.

Results

The mean distance between the central points of crystalline lens plane and limbus plane was approximately 0.33 ± 0.18 mm. The distance of the center of the limbus plane relative to the CV was approximately 0.31 ± 0.14 mm, which approximated the distance of the center of the crystalline lens plane relative to the CV at 0.33 ± 0.20 mm (P = 0.354). However, the centers of the limbus and crystalline planes were not in the same quadrant in 80% of eyes (24/30). Moreover, the crystalline lens tilted by approximately 4.16° ± 1.97° relative to the CV.

Conclusions

The center of the limbus plane was not consistent with that of the crystalline lens plane. The tilt and decentration of the crystalline lens were natural phenomena.

Translational relevance

The SS-OCT technology combined with 3D reconstruction was useful for quantifying the tilt and decentration of the crystalline lens. The definition of angle alpha used for premium IOL screening should be updated.

SUBMITTER: Dong J

PROVIDER: S-EPMC8363763 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Three-Dimensional Reconstruction and Swept-Source Optical Coherence Tomography for Crystalline Lens Tilt and Decentration Relative to the Corneal Vertex.

Dong Jing J Wang Xiao-Liang XL Deng Minghui M Wang Xiao-Gang XG

Translational vision science & technology 20210801 9

<h4>Purpose</h4>To investigate crystalline lens tilt and decentration with respect to the corneal vertex (CV) using swept-source optical coherence tomography (SS-OCT) combined with three-dimensional (3D) reconstruction.<h4>Methods</h4>Thirty consecutive patients with cataract (30 right eyes) were included in this prospective, observational, pilot case series study. SS-OCT anterior segment images and 3D reconstructions were used for data analysis.<h4>Results</h4>The mean distance between the cent ...[more]

PMID: 34388238

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Project description:PurposeTo assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE).MethodsA corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k, defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from corneal bending). Elastographic maps displaying local k values across the cornea were generated, and the ratio of mean axial stiffness approximations for adjacent anterior and posterior stromal regions, ka/kp, was calculated. Intraclass correlation coefficients (ICC) were used to estimate repeatability.ResultsSeventeen eyes (ten subjects) were included in this prospective first-in-humans translational study. The ICC was 0.84. Graphs of force vs. displacement demonstrated that, for simultaneously acquired measurements involving the same applied force, anterior stromal displacements were lower (suggesting stiffer behavior) than posterior stromal displacements. Mean ka was 0.016±0.004 g/mm and mean kp was 0.014±0.004 g/mm, giving a mean ka/kp ratio of 1.123±0.062.ConclusionOCE is a clinically feasible, non-invasive corneal biomechanical characterization method capable of resolving depth-dependent differences in corneal deformation behavior. The anterior stroma demonstrated responses consistent with stiffer properties in compression than the posterior stroma, but to a degree that varied across normal eyes. The clinical capability to measure these differences has implications for assessing the biomechanical impact of corneal refractive surgeries and for ectasia risk screening applications.

Dataset Information

Three-Dimensional Reconstruction and Swept-Source Optical Coherence Tomography for Crystalline Lens Tilt and Decentration Relative to the Corneal Vertex.

Purpose

Methods

Results

Conclusions

Translational relevance

Publications

Three-Dimensional Reconstruction and Swept-Source Optical Coherence Tomography for Crystalline Lens Tilt and Decentration Relative to the Corneal Vertex.

Similar Datasets

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